South Italy/America is a common Romano pairing found in the fandom, though there are no indication of these characters having romantic interactions in the cannon.

It is thought of as the same concept as Spamano. America, similarily to Spain, is very cheerful and affectionate, whereas Romano is a tsundere character.

Fans counter that this pairing is possible, the same way America/England or England/America, Spain/Romano and Spain/England are possible, with one character being tsundere and the other being cheerful and affectionate.