South Italy/Canada is a relatively uncommon pairing.

Most fans defend the pairing by saying that both Canada and Romano are overshadowed by their brothers, with Canada being invisible to everyone but America, England and France, despite him being part of the G8 and the 2nd largest country in the world, and Romano always believing that everyone likes his brother, Italy, who is sweeter and in general kinder better then him.

The pairing is also similar to Prussia/Canada and Prussia/Romano, as both of the characters characters being considered to feel inferior to their brothers, and bonding over that.